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& Jewett, M

Introduction: The Hygiene Hypothesis The incidence of autoimmune diseases, such as inflammatory bowel disease (IBD), multiple sclerosis (MS) and type1 diabetes (T1D) in industrialized countries has continuously increased over the past 50 years, and continues to rise steadily ( The observation that increasing hygiene in industrialized countries and the resulting low incidence of infectious diseases correlates with an increasing prevalence of allergic and autoimmune diseases, led to the postulation of the hygiene hypothesis in 1989 ( Bacteria, viruses and parasites have all been implied as players in the hygiene hypothesis ( Plasmodium berghei ( Schistosoma (S.) mansoni is one of the most commonly encountered helminth infections and its immunomodulatory properties (outlined in Figure 1) have been studied extensively ( S