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Tandem mass tag-based quantitative proteomic analysis of the liver reveals potential protein targets of Xiaochaihutang in CUMS model of depression

Revised: 29-Mar-2023, Manuscript No

doi: 10.1073/pnas.210394297 180 RubinJAckert-BicknellCLZhuLFanXMurphyTCNanesMSet al

Although the number of cases and deaths decreased between 1990 and 2019, influenced by COVID-19, the global burden of sepsis increased in 2021, with an estimated 166 million sepsis cases and 21.4 million sepsis-related deaths worldwide (GBD 2021 Global Sepsis Collaborators, 2025)

As a key enzyme in the tricarboxylic acid cycle, MDH2 play a non-metabolic role in ccRCC progression by reducing FSP1 protein levels and increasing the ccRCCs sensitivity to ferroptosis (148)