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48 The human GSTP1 gene exists as two functionally different variants, with both variants having documented nucleotide transitions from isoleucine to valine at codon 105 (AG) and alanine to Val at 114 (CT)

Clinician Perspective The ADA Standards of Care 2024 state directly: "Routine supplementation with antioxidants, such as vitamins E and C and carotene, is not advised because of lack of evidence of efficacy and concern related to long-term safety." [6] Glutathione is not explicitly addressed in this language, but the guidance reflects a broader evidentiary standard the ADA applies to antioxidant supplements in diabetes management