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The model selection was based on goodness-of-fit criteria, which included the convergence criterion, the Akaike information criterion, the estimation criterion value for the maximum likelihood method, and the visual inspection of predicted versus observed and residual plots

It has diverse physiological functions, including protection against reactive oxygen species and nitrogen species, antioxidant defense as well as maintenance of cellular thiol status

Secretion of Exe4 peptide via gene knock-in in Hepa1-6 cells To achieve sustained Exe4 secretion, we targeted the Albumin ( Alb ) locus due to its hepatocyte-specific high expression levels, ensuring robust expression of the integrated scExe4 gene 9,33,34