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Prophylactic treatment of curcumin in a rat model of depression by attenuating hippocampal synaptic loss

363 MDM2 inhibition and wild-type p53 activation, which involves the activation of p53-targeted genes, including CDKN1A, BBC3, and Bax, and the induction of apoptosis, have beneficial effects on refractory/relapsed (R/R) AML and chronic myeloid leukemia (CML) patients

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Endocr Rev 35:851905

Future treatment strategies focus on combination therapies that work across multiple metabolic pathways simultaneously, creating a more comprehensive approach to conditions such as diabetes, obesity, and cardiovascular disease