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Beyond its primary indications for diabetes and weight management, tirzepatide demonstrates additional therapeutic benefits, including reducing all-cause cardiovascular risk in patients with diabetes and obesity, as well as improving blood pressure and lipid profilesspecifically lowering low-density lipoprotein cholesterol and triglycerides

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For injections, food timing doesn't matter because the peptide bypasses the digestive tract entirely

To allow comparable reduction kinetics, the proteins were pre-oxidized with 10 mM H 2 O 2 for 30 min

We assessed the positivity assumption within each exposure set and observed good overlap between the propensity score distributions (supplementary figure B)