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doi: 10.3389/fnins.2023.1203514 273 TappZMGodboutJPKokiko-CochranON

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Studies show that MDA levels significantly increase in IL-1- or erastin-induced OA mouse models, while 4-HNE and its protein adducts rise in the synovial fluid and chondrocytes of OA patients, underscoring the critical role of lipid peroxidation in OA pathology (Grigolo et al., 2003