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In a randomised, placebo-controlled double blinded phase 1 study of ascending single doses in healthy overweight humans, cotadutide was shown to be safe and, in common with the GLP-1 analogues, to be associated with dose-dependent gastrointestinal adverse events especially nausea and vomiting

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Results: We found one Chinese patient with two heterozygous variants of unknown significance (VUS) in VPS13C [p.C2588F

Start with a 4- to 6-week series Then switch to weekly or monthly maintenance Many of our patients continue long-term as part of their wellness plan

Adding long alkane chains makes these drugs more sticky than ordinary peptide/protein drugs, making it extremely easy to cause adsorption and residue in the LC-MS/MS system