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The glutaminase inhibitor CB-839 targets metabolic dependencies of JAK2-mutant hematopoiesis in MPN

Adrenalectomy in female rodents, although removing considerable production of DHEA, and thus peripheral conversion of testosterone, would not seem to be an improved methodology due to the subsequent loss of other peptide and steroid hormones produced within, including, epinephrine, norepinephrine, cortisone, cortisol, and aldosterone