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Significantly, a major challenge currently lies in the selective targeting of lactylation without affecting other PTMs, as they are intricately linked and share a common set of regulatory enzymes, such as p300, HDACs, and Sirts, complicating the specific inhibition of lactylation

Activation of PPAR coactivator-1 through transcription factor docking

Supplementation of GLY alone was selected as opposed to GLY and CYS since CYS can be toxic (Reference Osman, Mitchell and Waring29)

Clinical trial data have demonstrated that tirzepatide achieves unprecedented improvements in both glycemic control and weight reduction

doi: 10.1016/j.jsbmb.2020.105607CrossRefGoogle ScholarPubMed