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PLoS Biol

However, PVN Glu -specific MOR knockdown did not significantly impact colonic dysfunction (Supplementary Fig

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At the molecular level, astaxanthin upregulates synaptic proteins involved in both pre- and postsynaptic function, such as synaptophysin, PSD-95, and SNAP-25, while promoting neurotrophic signaling through the BDNF/TrkBCREB pathway

Funding This study was supported by grants from the National Natural Science Foundation of China (82302925, 82272702), Natural Science Foundation of Zhejiang Province (LQ23H160012, LZ23H160001, LTGY23H080005), the project of Science and Technology Plan of Traditional Chinese Medicine of Zhejiang Province (2024ZL1010), Wenzhou Science and Technology Bureau of China (ZY2023021), and in part supported by the Key Discipline of Zhejiang Province in Medical Technology (First Class, Category A)