Rat Osteonectin, ON ELISA Kit , 96T Cell Senescence Cleaves the alpha-chain at multiple

Cleaves the alpha-chain at multiple sites and the beta-chain between 'Lys-53' and 'Lys-54' but not the gamma-chain of fibrinogen and therefore does not initiate the formation of the fibrin clot and does not cause the fibrinolysis directly

Members of this family are involved in regulating intracellular concentrations of diacylglycerol and phosphatidic acid

6-kb minor transcript in SNG-M cells and in human trophoblastic teratocarcinoma HT-H cells

cleaves many transcription factors such as NF-kappa-B and cAMP response element-binding protein/CREBBP (PubMed: 10559921

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Rat Osteonectin, ON ELISA Kit , 96T Cell Senescence Cleaves the alpha-chain at multipleMajor non collagenous bone protein that binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell matrix interaction. Acts as a cytokine involved in enhancing production of interferon gamma and interleukin 12 and reducing production of interleukin 10 and is essential in the pathway that leads to type I immunity.