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Brain indoleamine 2,3-dioxygenase contributes to the comorbidity of pain and depression

These conditions are also typified by loss of mitochondrial health through dysfunction of homeostatic components such as mitophagy, unfolded protein response, and the antioxidant system

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Studies suggest that lowering NNMT levels may help counteract some of the mechanisms underlying impaired stem cell function in these disorders

Similarly, experimental studies has shown that treatment with coenzyme Q10 and VE, whether administered separately or together, results in blockade of the NF-B/NLRP3 inflammasome pathway [32]