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References accessed July 25, 2025

This fear originated from preclinical data showing that these drugs could make thyroid C-cells proliferate in rodent models

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Comparative work with semaglutide (GLP-1R only) and tirzepatide (GIPR + GLP-1R) provides the field with a comprehensive map of how incremental receptor engagement reshapes downstream pharmacology across pancreatic, hepatic, adipose, and central nervous system tissues