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Wagner et al., 2002

They are generally larger (500-3000 Da) than conventional small molecules, better suited to exploit the flat and hydrophobic interfaces characteristic of PPIs, and can exhibit antibody-like binding affinity and specificity with just a small fraction of their molecular weight

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Headaches occasionally occur, particularly during initial use periods

(2013) Chemoenzymatic synthesis and in situ application of S-adenosyl-l-methionine analogs, Org