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Glucose metabolism remained unaffected

The largest published trial (METAOD006/OPTIONS) randomized 502 adults with obesity to AOD-9604 or placebo for 24 weeks alongside a diet and exercise program

A comprehensive review by Pickart, Vasquez-Soltero, and Margolina (2015), documented GHK-Cus ability to reset gene expression patterns in aged or damaged tissue toward a more regenerative state, affecting over 4,000 human genes