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Medical supervision is crucial as it enables healthcare providers to create individualized dosing plans, monitor side effects, and minimize the risk of potential interactions between GLP-1 medications and other medications or health conditions

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The difference in results of clinical trials could be due either to a different case mix or to possible prescription bias: since the summary of product characteristics in the US and Europe, 23 , 24 on the basis of preclinical studies only, warns of possible risks in patients with a personal or familial history of medullary carcinoma, physicians could be less prone to prescribe a GLP1RA in patients with thyroid nodules, which are often not reported in large databases used for retrospective observational studies

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