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Clinical trials have consistently shown significant reductions in body weight, often in the range of 15.8% or 33.7 lbs., when GLP-1 medications are combined with a healthy diet and exercise

IMU-856, which targets the protein Sirtuin 6 (SIRT6), is intended to restore intestinal barrier function and regenerate bowel epithelium, which could potentially be applicable in numerous gastrointestinal diseases, such as celiac disease as well as inflammatory bowel disease, Graft-versus-Host-Disease and weight management

If fatigue persists despite these interventions, or if it is accompanied by other concerning symptoms, further medical evaluation is warranted to exclude alternative diagnoses

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Given the drugs many side effects and their impact on a patients overall well-being, quality of life, and productivity, nonadherence becomes a major risk when GI symptoms are not managed successfully