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However, the translation of these findings to human obesity remains limited by important physiological differences between rodents and humans, including the lower abundance and activity of brown adipose tissue in adults and an overall reduced thermogenic capacity

Glycosuria contributes directly to improved glycemic control, while increased distal sodium delivery restores normal tubuloglomerular feedback, thereby lowering intraglomerular pressure, which is a key mechanism in slowing DKD progression [25,27]