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Among the remaining subjects, we further excluded those who received a diagnosis of bipolar disorder during the follow-up assessment (n = 9), those with missing metabolite data due to the lack of blood samples (n = 158) and those who did not complete the Inventory for Depressive Symptoms questionnaire (n = 33)

RESULTS The behavioral response of the rats upon injection of a 5% formalin solution into the hindpaw was described more than 30 years ago to assess pain and analgesia

(2019) showed that diabetes could damage the integrity of the Neurovascular unit (NVU) in the hippocampus and reduce BDNF levels in endothelial cells and HT22 hippocampal neurons