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In the SELECT trial, which included more than 17,000 patients with obesity and cardiovascular disease but not diabetes, semaglutide cut the rate of major cardiac events by 20%

Extended-release exenatide (Bydureon BCise) has an apparent terminal half-life of approximately 2 weeks due to its depot formulation, with drug concentrations potentially persisting for 8-10 weeks after discontinuation

Contrarily to GPR40, the genetic deficiency of GPR120 is more dramatic

Their change in creatinine was compared to patients with no GLP-1 exposure who had office visits in the same period

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