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Whilst often troublesome, these effects typically diminish as the body adjusts to treatment

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Hypoxia response element of the human vascular endothelial growth factor gene mediates transcriptional regulation by nitric oxide: control of hypoxia-inducible factor-1 activity by nitric oxide

In addition, liver cirrhosis and obstructive liver disease, which can inhibit enterohepatic circulation, were reported to increase the daily doses of LT4 required (32)