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Their relevance to eye-area aging is particularly strong because they work through multiple mechanisms

In addition to the 334 amino acid protein, one of the alternatively spliced LDHB mRNAs encodes a distinct 341 amino acid protein identified as LDHBx

In this Ground Truths post Ill review them by 2 categories: (1) the peptides that have been FDA approved but are getting extensive off-label use

These are the observable outcomes ordered by when they typically appear

Furthermore, mutations in the autosomal recessive genes Parkin (PRKN), PTEN-induced kinase 1 (PINK1), and Parkinsonism associated deglycase 1 (DJ-1) contribute to the pathogenesis of autosomal recessive PD (Di Rita et al., 2018)