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Evaluation of novel acute urinary rat kidney toxicity biomarker for subacute toxicity studies in preclinical trials

Oxidative stress and mitochondrial function Cardiac overexpression of beta-hydroxybutyrate dehydrogenases 1 (BDH1) in mice resulted in 1.7-fold increase in cardiac ketone body oxidation, increased expression of antioxidant superoxide dismutase, and suppressed oxidative stress after transaortic constriction (TAC) (44)

Considering the physiological role of selenoproteins in antioxidation and the detrimental effects of oxidative stress in chondrocytes, aberrant selenium metabolism is likely to disrupt cartilage homeostasis and cause arthropathic diseases via dysregulation of redox homeostasis (Fig