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This may be attributed to the dimeric structure which hinders enzyme access to active sites, showcasing significant resistance to enzymatic degradation 49,55

doi: 10.1038/s41598-023-39890-0 202 LinZ.AkinH.RaoR.HieB.ZhuZ.LuW.et al

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Adipose tissue in insulin-resistant states releases increased free fatty acids and inflammatory cytokines such as tumor necrosis factor-alpha and interleukin-6, which interfere with insulin signaling pathways at the cellular level