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After receptor binding, intracellular pathways, including PI3K/Akt/mTOR and MEK/ERK, are activated, contributing to protein synthesis and anabolic signaling

Metformin activates AMPK/SIRT1/NF-B pathway and induces mitochondrial dysfunction to drive caspase3/GSDME-mediated cancer cell pyroptosis

Availability of data and materials The datasets used and/or analyzed in this current study are available from the corresponding author on reasonable request