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Unresolved safety questions The staff review identified uncertainty about immunogenicity, aggregation, peptide-related impurities, hypersensitivity, route-specific risk, repeated exposure, and long-term use

Research progress Support The animal experiments have achieved remarkable results: In the obese mouse model, after daily subcutaneous injection of AOD 9604 (250 g/kg) for 8 weeks, the body weight of the mice decreased by 12%, the subcutaneous fat mass decreased by 25%, and the weight of epididymal adipose tissue significantly decreased, confirming its effectiveness in fat reduction