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J Comp Physiol Psychol 84(3):488495 Gutzwiller JP, Drewe J, Gke B, Schmidt H, Rohrer B, Lareida J et al (1999) Glucagon-like peptide-1 promotes satiety and reduces food intake in patients with diabetes mellitus type 2

GLP-1 medications like semaglutide protect the brain by improving blood vessel health, reducing inflammation, and potentially impacting metabolic processes linked to Alzheimer's disease

An active-comparator new-user cohort design is less susceptible to healthy user bias and confounding by indication, because an active treatment with similar indication rather than non-users is the comparator [31, 32]

By week 16, a larger proportion of AXA1125-treated subjects (3540%) than those in the placebo group (825%) reached clinically relevant thresholds for MRI-PDFF reductions of 30%, ALT reductions of 17 IU/L, and cT1 reductions of 80 ms

Clear statements about tissue layers traversed, technique used, and accessibility of the bone eliminate this issue