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Vekovischeva OY, Zamanillo D, Echenko O, Seppala T, Uusi-Oukari M, Honkanen A et al (2001)

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Childhood hypotonia, or low muscle tone, is another hallmark feature that affects motor skills and leads to developmental delays in milestones such as sitting, crawling, and walking

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(2) EGCG induces M1 polarization via various signaling pathways including TLR4/NF-B, JAK2/STAT3, TLR2, TLR4, JNK/P38, thereby suppressing the activation of inflammatory vesicles and reducing microglial inflammation and neurotoxicity (13)