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Encourage patients to aim for at least 10 cups (80 oz or 2.5 liters) of fluids per day

How are payors and providers balancing the high upfront costs of GLP-1s with delayed realization of long-term health benefits in value-based care models?

Evaluations of the model will also determine whether improvements in health related to the use of these drugs and associated reductions in health care utilization are significant enough to maintain or reduce health care costs in the Medicaid and Medicare programs, after taking into account expanded use and coverage of GLP-1s for the treatment of obesity

It has a short half-life in blood of 1.5-3 min due to a high clearance but also activates afferent nerve endings directly before entering the blood