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Tirzepatide longer half-life of approximately 5 days is what allows once-weekly dosing

In this large multisite study, utilizing data from six population-based databases, we found no evidence that GLP1-RA use is associated with an increased risk of thyroid cancer with follow-up ranging from 1.8-3.0 years, providing some reassurance to patients and clinicians about the short-term safety of these drugs, concluded the investigators

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This means that improperly stored medication may fail to provide adequate glycemic control or weight management benefits, even if it appears visually unchanged

Some researchers argue this indirect risk may be more clinically relevant than the drug itself entering milk