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Under normal conditions, NRF2 is recognized and ubiquitinated by the Keap1-Cul3 E3 ligase complex, marking it for proteasomal degradation and maintaining its low levels in the cell

In this case, glutathione IV therapy may be a better option

Ox-LDPE, oxidized low-density polyethylene

A number of therapies that target fibroblast activation or the synthesis of extracellular matrix are currently in early testing or are being considered for development