retatrutide study news isn't supposed to be everywhere. Touted as the next generation in the GLP-1 craze, it's an experimental weight-loss drug that is not authorized outside of clinical trials. The Food and Drug Move over #retatrutide the #QuintupleAgonist

The key is getting protected through that early window usually low-dose colchicine or adjusting your urate-lowering therapy

By inhibiting NNMT, 5-Amino-1MQ prevents the methylation of nicotinamide, which thus remains available for recycling to NAD+ via the salvage pathway

Title: Structural insights into ligand recognition and activation of the melanocortin-4 receptor Authors: Huibing Zhang, Li-Nan Chen, Dehua Yang, Chunyou Mao, Qingya Shen, Wenbo Feng, Dan-Dan Shen, Antao Dai, Shanshan Xie, Yan Zhou, Jiao Qin, Jin-Peng Sun, Daniel H

And I'll say, reading the book doing all the sort of thinking and research about GLP-1s and then reading the book kind of felt like reading a book from another era

Together, these improvements could promote the extension of meta-omics applications into diverse fields beyond microbiome research, enabling more widespread and effective use of this data in areas such as personalized medicine, diagnostics, and treatment strategies (Filardo et al., 2024)