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In laboratory settings, FOXO4-DRI is used as a research reagent for experimental systems examining FOXO4-p53 protein interaction disruption, senescent cell modeling, DNA damage signaling assays, and oxidative stress research

Lung-abundant antioxidant proteins with known extracellular location include Gpx1 36 , Gpx3 32,33 , Sod3 37 , peroxiredoxin IV (Prdx4) 31 , and peroxiredoxin VI (Prdx6) 38