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GSH depletion studies: using a laboratory inhibitor such as buthionine sulfoximine (BSO) and confirming the result by direct GSH measurement

Comparison of bacterial and fungal biodiversity of Turkish Kefir grains with high-throughput metagenomic analysis

Saxagliptin has also been evaluated in five additional trials in patients with type 2 diabetes mellitus: an active-controlled trial comparing add-on therapy with saxagliptin to glipizide in 858 patients inadequately controlled on metformin HCl alone, a trial comparing saxagliptin to placebo in 455 patients inadequately controlled on insulin alone or on insulin in combination with metformin HCl, a trial comparing saxagliptin to placebo in 257 patients inadequately controlled on metformin HCl plus a sulfonylurea, a trial comparing saxagliptin to placebo in 315 patients inadequately controlled on dapagliflozin and metformin HCl, and a trial comparing saxagliptin to placebo in 170 patients with type 2 diabetes mellitus and moderate or severe renal impairment or ESRD

By extending its patent protection through minor modifications, Eli Lilly seeks to maximize the lifecycle of its products while erecting as many barriers of entry for competitors as possible in order to increase the prospects of prolonging its market monopoly and profits