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LKB1 mutations in NSCLC are associated with KEAP1/NRF2-dependent radiotherapy resistance targetable by glutaminase inhibition

Orthotopic model of lung cancer Stably transfected KP tumor cells expressing luciferase (KP-Luc) were injected into the tail vein of 6-week-old C57BL/6 mice, with each mouse receiving a 100 L PBS suspension containing 5 10 5 proliferating cells