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The maintenance of stable holotranscobalamin in pregnancy is considered to be a result of mobilisation of maternal B 12 pools to safeguard the adequate B 12 supply to the fetus

[3] It is contraindicated in uncontrolled hypertension and is not recommended for people with significant cardiovascular disease

Hydroquinone provides faster, more dramatic results but requires careful monitoring and professional guidance

In addition, most clinical studies involve short treatment durations (often 412 weeks) or limited follow-up, as seen in trials evaluating C

Resveratrol induces glutathione synthesis and protects against oxidative stress