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18 Figure 35: SF-36v2 change from baseline at week 26, PIONEER 10 (FAS) CI = confidence interval

It simultaneously activates three hormone receptors that play central roles in metabolism, appetite regulation, and energy balance: Glucagon-like peptide-1 (GLP-1) receptor Glucose-dependent insulinotropic polypeptide (GIP) receptor Glucagon receptor Previous weight loss medications have targeted one or two of these pathways

Zhu, M., Rhee, I., Liu, Y

After a 20-week run-in, participants randomized to placebo had a body weight change of +6.9% from week 20 to week 68, while those who continued semaglutide changed 7.9%, a difference of 14.8 percentage points

In rare cases, some people have experienced severe allergic reactions to bupropion, including rash, hives, swelling of the mouth and tongue, itching, and trouble breathing