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This provides marginal benefit compared to semaglutide's seven-day half-life

Seino, Y., Terauchi, Y., Osonoi, T., et al

Figure 3 also highlights that more than half of all De Novo submissions to date are clustered into five primary medical specialty areas (as defined by their respective FDA advisory committees), namely microbiology (14.4%), neurology (11.22%), general and plastic surgery (10.69), gastroenterology/urology (8.5%), clinical chemistry (7.75%) and cardiovascular (6.9%)

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"While the label only recently added a warning of severe gastrointestinal adverse reactions, it has always indicated nausea and vomiting are common side effects during dose escalation, but the messaging from Novo Nordisk has downplayed these effects as manageable and minor when the reality is these can be life threatening conditionsthey are not just uncomfortable side effects