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Modulating effects of RAMPs on signaling profiles of the glucagon receptor family

No significant drug-drug interactions exist between these medication classes

10.1038/s41419-025-07445-y 44

Risk factors include kidney or liver impairment, older age, surgery, low oxygen levels, and heavy alcohol use

SURPASS-5 (Add-on to Insulin Glargine) To assess its utility in patients with advanced T2D, the SURPASS-5 trial evaluated Tirzepatide as an add-on therapy to titrated insulin glargine, with or without metformin, in 475 patients