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Discussion Given the significant increase in prevalence and burden of obesity globally, there is a need to explore and establish available treatment modalities and their outcomes

A 2021 study in *Diabetes Care* found that participants using lower semaglutide doses lost meaningful weight while experiencing fewer gastrointestinal side effects

Despite significant advances in MASLD diagnosis [31, 32], histological assessment through a liver biopsy remains the gold standard for diagnosing, staging, and prognosing MASLD/MASH, as well as for accurately monitoring fibrosis progression [33]

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