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Zepbound received approval in November 2023 for chronic weight management in adults with obesity or overweight plus a weight-related condition, and in December 2024 for moderate-to-severe obstructive sleep apnea in adults with obesity

Conclusion When administered acutely, T

injections of 100 nmol kg 1 MK-801 ( n = 10), 100 nmol kg 1 GLP-1 ( n = 10), 100 nmol kg 1 GLP-1MK-801 ( n = 10) or vehicle (isotonic saline, n = 10) for 14 days