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Thus, RBCs obtained from patients with sickle cell anemia show decreased deformability (in bulk volumes) and settle at greater sedimentation heights, which can be used as diagnostic markers for the disease 44

Combining our findings and the evidence above, the effects of IL-1 and IL-18 cannot fully explain the decreased angiogenesis and perfusion recovery

For instance, highly charged peptides may require specific lipid compositions or pH conditions to optimize electrostatic interactions, while large proteins may demand larger vesicles or multilamellar structures