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MILES ( commenced October 2014 and was conducted on 14 elderly participants with impaired glucose tolerance to determine whether metformin (1700 mg/day) can cause physiological and transcriptomic changes in muscle and adipose tissues after 6 weeks of treatment and also to determine which pathways are affected by metformin and outline possible molecular intermediates involved in metformins mechanism of action ( Dysregulation of adipose tissue metabolism has been previously linked to an agerelated process of ECM deposition and the effects of metformin on fatty acid metabolism have been previously shown to mimic those of other interventions that increase lifespan in model organisms (259, 260)

3.4.3 Weight changes Concerning weight change, Tirzepatide did not demonstrate clear superiority over Semaglutide, with a pooled effect size of 2.57 (95% CI: 6.771.62