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One week of daily dosing with beetroot juice improves submaximal endurance and blood pressure in older patients with heart failure and preserved ejection fraction

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In several RCTs, GLP-1RAs, when used alone or in combination with other hypoglycemic agents including metformin, sulfonylurea, DPP-4 inhibitor, thiazolidinedione, and sodium-glucose cotransporter 2 inhibitor, showed superior or non-inferior blood glucose lowering ability compared to insulin treatment [64,65]

Allerdings relativiert die niedrigere systemische Bioverfgbarkeit diesen Vorteil: Wenn ein geringerer Anteil der Dosis systemisch ankommt, wird pro erzieltem systemischem Effekt unter Umstnden mehr Substanz bentigt