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Those generic parts are attached to a central alpha carbon (Ca), which is also attached to one of 20 unique side chains (R groups) which have different properties (big, small, hydrophilic (water-loving), hydrophobic (water-avoided), etc.) & proteins have different combos of them, so the proteins have different properties

The GLP-1 receptor exists in the brain, the gut, the pancreas, the heart, and even muscle tissue

Toxicol Appl Pharmacol 195: 1222

Some physical health conditions, like obesity or injuries to the blood vessels, can make it easier for a clot to form