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gratefully acknowledges support from NIH GM066099

Initial information indicates a majority of the weight loss occurs within the first 24 weeks, demonstrating a rapid time to onset

Costs, coverage, and access Coverage varies

Taking Contrave with a monoamine oxidase inhibitor (MAOI) or within 14 days of stopping one may increase the risk of a severe increase in blood pressure (hypertensive crisis)

Early results from the REDEFINE-4 trial showed that participants lost an average of 22.7% of their body weight, making it a potential competitor to existing treatments