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While sometimes they are harmless and temporary, other times they can signal an underlying health issue

[PubMed] [Google Scholar] 18.Pickart L

Once bound to the antioxidant response element (ARE), Nrf2 upregulates cytoprotective genes such as Heme Oxygenase-1 (HO-1) and NAD(P)H: Quinone Oxidoreductase 1 (NQO1) (Kim et al., 2017