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In addition, these genes were enriched in molecular functions such as antioxidant enzyme activity, phospholipase regulation, and peroxidase activity, suggesting their crucial roles in immune regulation and metabolic processes in RA

It is worth noting that recently, studies evaluating whether vitamin D supplementation is beneficial for autoimmune thyroid disease have been published

At the same time, it also preserves lean muscle mass, which further boosts the metabolism

Glutamate can also be formed from another amino acid, glutamine through the enzyme glutaminase and then further metabolised as described above (Pisarenko 1996)

Other immunoregulatory genes are involved in the development of HT, including the single nucleotide polymorphisms (SNPs) in cytotoxic T lymphocyte-associated antigen 4 (CTLA-4), protein tyrosine phosphatase non-receptor type 22 (PTPN22), and CD40 [2,4,6,7,18,19,20]