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Furthermore, A316T shows enhanced recruitment of G s and endocytosis in response to oxyntomodulin, GLP-1, Semaglutide and Tirzepatide, but not Exenatide (Lagou et al., 2021)

When we evaluated FcRn-mediated recycling in a cell-based assay, where the receptor is embedded in the membrane, the WT fusion was recycled 1.8-fold less efficiently than unfused WT albumin, which is in line with its shorter plasma half-life